Detalhe da pesquisa
1.
Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer.
Nature
; 578(7794): 306-310, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31969702
2.
Periplasmic protein EipA determines envelope stress resistance and virulence in Brucella abortus.
Mol Microbiol
; 111(3): 637-661, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30536925
3.
Brucella Periplasmic Protein EipB Is a Molecular Determinant of Cell Envelope Integrity and Virulence.
J Bacteriol
; 201(12)2019 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30936371
4.
The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.
Nat Chem Biol
; 13(4): 389-395, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28135237
5.
Structural Insights into the Free-Standing Condensation Enzyme SgcC5 Catalyzing Ester-Bond Formation in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027.
Biochemistry
; 57(23): 3278-3288, 2018 06 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29533601
6.
Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases.
Proc Natl Acad Sci U S A
; 112(41): 12693-8, 2015 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26420866
7.
How Aromatic Compounds Block DNA Binding of HcaR Catabolite Regulator.
J Biol Chem
; 291(25): 13243-56, 2016 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-27129205
8.
Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus.
Biochemistry
; 55(36): 5142-54, 2016 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27560143
9.
Structural Characterization of CalS8, a TDP-α-D-Glucose Dehydrogenase Involved in Calicheamicin Aminodideoxypentose Biosynthesis.
J Biol Chem
; 290(43): 26249-58, 2015 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-26240141
10.
Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892.
Biochemistry
; 54(45): 6842-51, 2015 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26512730
11.
Structural characterization of AtmS13, a putative sugar aminotransferase involved in indolocarbazole AT2433 aminopentose biosynthesis.
Proteins
; 83(8): 1547-54, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26061967
12.
The crystal structure of BlmI as a model for nonribosomal peptide synthetase peptidyl carrier proteins.
Proteins
; 82(7): 1210-8, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25050442
13.
Erratum: The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.
Nat Chem Biol
; 13(8): 922, 2017 Jul 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28853738
14.
Data collection from crystals grown in microfluidic droplets.
Acta Crystallogr D Struct Biol
; 78(Pt 8): 997-1009, 2022 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35916224
15.
An anti-PD-1-GITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy.
Nat Cancer
; 3(3): 337-354, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35256819
16.
3D domain swapping in the TIM barrel of the α subunit of Streptococcus pneumoniae tryptophan synthase.
Acta Crystallogr D Struct Biol
; 76(Pt 2): 166-175, 2020 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32038047
17.
Conservation of the structure and function of bacterial tryptophan synthases.
IUCrJ
; 6(Pt 4): 649-664, 2019 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31316809
18.
Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events.
Structure
; 27(3): 449-463.e7, 2019 03 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30595457
19.
Insights into PG-binding, conformational change, and dimerization of the OmpA C-terminal domains from Salmonella enterica serovar Typhimurium and Borrelia burgdorferi.
Protein Sci
; 26(9): 1738-1748, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28580643
20.
Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis.
ACS Omega
; 2(8): 5159-5169, 2017 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-28884166